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Release of neurotransmitters into synapses requires synaptic vesicle docking, priming and fusion with the neuronal plasma membrane. Proteins on the synaptic vesicles and proteins associated with the plasma membrane form a soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor SNARE ; complex that holds synaptic vesicles adjacent to the plasma membrane. Following maturation into a fusion-competent state, fusion of vesicles with the plasma membrane is triggered by the presence of calcium. UNC-13 proteins interacts with several proteins involved in regulating neurotransmitter release including Doc2, -spectrin, RIM-1, UNC-18, and syntaxin Betz et al., 1997; 2001; Orita et al., 1997; Sakaguchi et al., 1998; Sassa et al., 1999 ; . UNC-13 promotes a change in syntaxin from a closed to open conformation so that it can associate with synaptobrevin and SNAP-25 in the SNARE complex Richmond et al., 2001 ; . UNC-13 function is regulated by signal transduction pathways. In Drosophila melanogaster, GS and Gq pathways regulate abundance of Drosophila UNC-13 DUNC-13 ; at synapses through proteasomal degradation Araa and atarax. 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Goldfinger R, Ahmed KS, Pitchumoni CS, Weseley SA. Concomitant alcohol and drug abuse enhancing acetaminophen toxicity. Report of a case. J Gastroenterol 1978; 70: 385388. Canalese J, Gimson AE, Davis M, Williams R. Factors contributing to mortality in paracetamol-induced hepatic failure. Br Med J Clin Res Ed ; 1981; 282: 199201. Bray GP, Harrison PM, O'Grady JG, Tredger JM, Williams R. Longterm anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure. Hum Exp Toxicol 1992; 11: 265270. Crippin JS Acetaminophen hepatotoxicity: potentiation by isoniazid. J Gastroenterol 1993; 88: 590592. Nolan CM, Sandblom RE, Thummel KE, Slattery JT, Nelson SD. Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis. Chest 1994; 105: 408411. Whitcomb DC, Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 1994; 272: 18451850. Makin AJ, Wendon J, Williams R. A 7-year experience of severe acetaminophen-induced hepatotoxicity 19871993 ; . Gastroenterology 1995; 109: 19071916. Washio M, Inoue N. The risk factors of death from the acetaminophen poisoning with antipyretic-analgesic drugs in Japan. Fukuoka Igaku Zasshi 1997; 88: 352357. Makin A, Williams R. Paracetamol hepatotoxicity and alcohol consumption in deliberate and accidental overdose. QJM 2000; 93: 341349. McCormick PA, Casey P, Barry P, Laffoy M, Treacy J. Delays in administration of acetylcysteine in paracetamol overdose. Ir Med J 2000; 93: 7778. Schiodt FV, Lee WM, Bondesen S, Ott P, Christensen E. Influence of acute and chronic alcohol intake on the clinical course and outcome in acetaminophen overdose. Aliment Pharmacol Ther 2002; 16: 707715. Schmidt LE, Dalhoff K, Poulsen HE. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology 2002; 35: 876882. Rumack BH Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol 2002; 40: 320. Shnaps Y, Halkin H, Dany S, Tirosh M. Inadequacy of reported intake in assessing the potential hepatotoxicity of acetaminophen overdose. Isr J Med Sci 1980; 16: 752755. Read RB, Tredger JM, Williams R. Analysis of factors responsible for continuing mortality after paracetamol overdose. Hum Toxicol 1986; 5: 201206. Thomas SH, Horner JE, Chew K, Connolly J, Dorani B, Bevan L, Bhattacharyya S, Bramble MG, Han KH, Rodgers A, Sen B, Tesfayohannes B, Wynne H, Bateman DN. Paracetamol poisoning in the north east of England: presentation, early management and outcome. Hum Exp Toxicol 1997; 16: 495500. Schiodt FV, Bondesen S, Tygstrup N, Christensen E. Prediction of hepatic encephalopathy in paracetamol overdose: a prospective and validated study. Scand J Gastroenterol 1999; 34: 723728. Rumack BH. Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases. J Dis Child 1984; 138: 428433. Gee P, Ardagh M. Paediatric exploratory ingestions of paracetamol. N Z Med J 1998; 111: 186188. Caravati EM. Unintentional acetaminophen ingestion in children and the potential for hepatotoxicity. J Toxicol Clin Toxicol 2000; 38: 291296. Tylenol product label. : tylenol products adult Accessed November 27, 2004 ; . 57. Gelotte C, Auiler J, Lynch J, Temple A., Bowen D Tolerability and repeat-dose pharmacokinetics PK ; of acetaminophen APAP ; at 4, 6 and 8 g d healthy adults. Toxicol Sci 2003; 72 S-1 : 145. 58. Chalmers TM, Pohl JE, Platt DS. Evaluation in man of fenclozic acid I.C.I. 54, 450: Myalex ; , a new anti-inflammatory agent. I. Serum concentration studies in healthy individuals and in patients with rheumatoid arthritis. Ann Rheum Dis 1969; 28: 590594. Grond S, Zech D, Lynch J, Diefenbach C, Schug SA, Lehmann KA. Validation of World Health Organization guidelines for pain relief in head and atorvastatin. He Common Carp grows large in lakes and in the quiet reaches of rivers - but may remain tiny in small ponds. It feeds mostly on vegetable matter, but shellfish are also eaten. It has a reputation for caution, cunning and tenacity. The largest British carp caught in 1958 weighed 44 lbs. So what can we learn from this wily creature well, for a start, `tiny ponds' are out, but that aside, the carp's lifestyle is to be encouraged, and better still, perhaps mimicked it maintains a healthy standard of living and nutrition, all the more able to fend for itself and its family, not only taking care of the food cycle and chain available but exercising and fighting tenaciously for its cause and corner. That's fairly similar to what your Charity advocates for its patients. HEART UK shares the good examples set and also goes the extra miles in fighting, in our case, for and representing patients at government level and with organisations and bodies that may help the charity achieve a better status and representation. And how has the carp fared since 1958? Well, like the charity it has grown grown outstandingly well, some would say. Your Treasurer said that the Charity's income had grown by 30% in the last year enabling HEART UK to continue to develop services it provides to people with cholesterol problems, and that the year had shown excellent income growth across all sectors. Your Chairman spoke of the enthusiasm and funding that will be represented next year by income from the London Flora Marathon when YOUR charity, as one of two selected Official Charities, will benefit hugely from additional income. An exciting prospect indeed, which I hope we shall ALL participate in hook, line and sinker not necessarily as runners, but as supporters of all kinds. The efforts to grow so far are being rewarded, and those to continue will benefit patients of the future. YOUR charity is, like the carp, tenacious - yes, active and fit -yes, and growing. Where, you might ask, is the carp today? Well on 23rd May this year, British angler Graham Slaughter scaled new heights by catching the world's biggest carp weighing in at a whopping 88.6lbs Keep it up Graham, and encore HEART UK. Definitely -- I would like to initiate another geriatric consulting service when I retire. For now, I want to mentor a body of pharmacists that have a passion for the geriatric population." This model demonstrates that there is a market for specialized and axid. Combined Nomenclature headings and corresponding PRODCOM codes - Year 2007 8714 96 00 10 36.63.72.30 8715 00 90 36.63.72.50 8716 00 29.32.50.40 8716 31 00 34.20.23.00 8716 39 Crank-gear for bicycles Crank-gear for bicycles and other non-motorized cycles Parts of pedals and crank-gear for bicycles, n.e.s. 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P158 PILOT STUDY OF ORBITAL EFFECTS OF RETROBULBAR INJECTION ON OPTIC NERVE HEAD TOPOGRAPHY Yusuf Akar, Iclal Yucel, Cemil Apaydin, Alper Ozel Akdeniz University, Dept. of Ophthalmology, School of Medicine, Antalya-Turkey PURPOSES To assess the effects of acute orbital volume changes after retrobulbar injection on optic nerve head topography. METHODS The study population consisted of 49 type II diabetes mellitus patients with clinically significant macular edema who required focal pattern laser photocoagulation therapy. Prior to each laser treatment, approximately 7 ml retrobulbar injection lidocaine HCl 2 with epinephrine and bupivacaine HCl 0.75 in equal volumes ; was used to provide ocular akinesia. Optic nerve head topographic analysis of both eyes were performed once within 30 minutes before injection, and repeated within one hour, one day, one week, two weeks and four weeks, respectively. Topographic analysis were performed using a confocal scanning laser ophthalmoscope, HRTII. Disc area, topography standard deviation and a total of 12 topographic parameters were calculated by HRT-II. RESULTS The mean age of the patients was 37.7 3.1 years. The mean disc area of the subjects was 2.13 0.05 mm2. In the first hour, first day and first week topographic exams, the disc area, rim area, rim volume, rim area disc area and cup shape measure parameters significantly increased while optic cup parameters significantly decreased all p values, 0.05 ; . By the fourth week, all of the optic nerve head topographic variables were found not to be different significantly from the pre-injection values all p values, 0.05 ; . CONCLUSIONS Acute orbital volume change following retrobulbar injection may cause significant topographic evidence of optic disc edema lasting approximately one-week. Significant changes in optic rim and cup area may last for two-weeks post injection, with all topographic changes from baseline disappearing by 1 month post injection. The present findings could be a model to reflect the pathological processes occuring in optic nerve head of cases with acute orbital volume increase namely retrobulbar hemorrhage. P159 THREE-DIMENSIONAL ANALYSIS TO DETECT GLAUCOMATOUS OPTIC DISCS BY USING THE HEIDELBERG RETINA TOMOGRAPH Fabio De Feo, Michele Iester, Michele Zanini * , Giuseppe Sanna, Simonetta Cicinelli, Marina Papadia, Carlo E. Traverso, Giovanni Calabria.
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138 Vongthavaravat V, Wajchenberg BL, Waitman JN, Quimpo JA, Menon PS, Ben Khalifa F, Chow WH, the 125 Study Group: An international study of the effects of rosiglitazone plus sulphonylurea in patients with type 2 diabetes. Curr Med Res Opin 18: 456461, 2002 Gomez-Perez FJ, Fanghanel-Salmon G, Antonio Barbosa J, Montes-Villarreal J, Berry RA, Warsi G, Gould EM: Efficacy and safety of rosiglitazone plus metformin in Mexicans with type 2 diabetes. Diabetes Metab Res Rev 18: 127134, 2002 Kipnes MS, Krosnick A, Rendell MS, Egan JW, Mathisen AL, Schneider RL: Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study. J Med 111: 1017, 2001 Miyazaki Y, Mahankali A, Matsuda M, Glass L, Mahankali S, Ferrannini E, Cusi K, Mandarino LJ, DeFronzo RA: Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone. Diabetes Care 24: 710719, 2001 Fonseca V, Grunberger G, Gupta S, Shen S, Foley JE: Addition of nateglinide to rosiglitazone monotherapy suppresses mealtime hyperglycemia and improves overall glycemic control. Diabetes Care 26: 16851690, 2003 Raskin P, Klaff L, McGill J, South SA, Hollander P, Khutoryansky N, Hale PM, the Repaglinide vs. Nateglinide Metformin Combination Study Group: Efficacy and safety of combination therapy: repaglinide plus metformin versus nateglinide plus metformin. Diabetes Care 26: 20632068, 2003 Marre M, Van Gaal L, Usadel KH, Ball M, Whatmough I, Guitard C: Nateglinide improves glycaemic control when added to metformin monotherapy: results of a randomized trial with type 2 diabetes patients. Diabetes Obes Metab 4: 177186, 2002 Garber AJ, Donovan DS Jr, Dandona P, Bruce S, Park JS: Efficacy of glyburide metformin tablets compared with initial monotherapy in type 2 diabetes. J Clin Endocrinol Metab 88: 35983604, 2003 Blaschke F, Bruemmer D, Law Will the potential of peroxisome proliferator-activated receptor agonists be realized in the clinical setting? Clin Cardiol 27 7 Suppl. 4 ; : IV3IV10, 2004 147 Ahren B: Gut peptides and type 2 diabetes mellitus treatment. Curr Diab Rep 3: 365372, 2003 Deacon CF: Therapeutic strategies based on glucagon-like peptide 1. Diabetes 53: 21812189, 2004 Bays HE: Current and investigational antiobesity agents and obesity therapeutic treatment targets. Obes Res 12: 11971211, 2004 Fonseca VA, Valiquett TR, Huang SM, Ghazzi MN, Whitcomb RW: Troglitazone 137.
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In 2004, several high-profile drug safety cases raised concerns about the Food and Drug Administration's FDA ; ability to manage postmarket drug safety issues. In some cases there have been disagreements within FDA about how to address safety issues. In this report GAO 1 ; describes FDA's organizational structure and process for postmarket drug safety decision making, 2 ; assesses the effectiveness of FDA's postmarket drug safety decision-making process, and 3 ; assesses the steps FDA is taking to improve postmarket drug safety decision making. GAO conducted an organizational review and case studies of four drugs with safety issues: Arava, Baycol, Bextra, and Propulsid and cabergoline and arava.

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In May 1995, the Company established a stock option plan for directors, executive officers, employees and consultants of the Company. The plan was amended in July 2002 to increase the maximum number of common shares that are issuable under the plan from 3, 000, 000 to 4, 650, 000 common shares. The maximum number of common shares that may be optioned in favour of any individual will not exceed 5% of the number of outstanding common shares. The price at which the common shares may be purchased will not be lower than the average of the closing price of the common shares on the Toronto Stock Exchange for the five preceding days. Any options issued will be non-transferable. All of the options that may be granted under the plan are exercisable according to a schedule up to a maximum period of ten years following the grant date thereof. The outstanding options as at December 31, 2002, may be exercised no later than December 2007. Options generally vest over a three-year period except for options to Board of Directors which vest immediately and cafergot.
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Leflunamide L ; SL2 ; . * ARAVA. 5 2.2. Local setting The NNE-SSW trending A5ava fault trace is outlined by scarps, small rhombshaped grabens, pressure ridges, and displaced alluvial fan toes indicating that strikeslip faulting is still active Galli, 1999; Klinger et al., 2000 ; . Proterozoic igneous rocks, Mesozoic sediments and young fluviatile and aeolian sands are exposed in the area around the AF. This study was carried out at two locations area A and B in Fig. 2a ; . In area A, the pressure ridges, where our structural analysis was mostly concentrated, exposed the exhumed part of the fault zone. The ridges consist of steeply dipping beds of limestones Fig.3a; Kesten, 2005 ; . Estimates of faulting conditions and the depth of faulting recorded in the exposure studied are not definitive. Janssen et al. 2004 ; use microstructures to argue that the uplifted Campanian-Turonian limestones were deformed at depth of 2-5 km. However, regional uplift and stratigraphic thickness indicate faulting depth of 1 to Wdowinski and Zilberman, 1997; DESERT, 2004; see discussion ; . Study area B is located in the southern Aeava Valley were the Upper Cretaceous limestones are weakly folded. The NE-SW striking Serghaya fault is a prominent structure within the 200 km restraining bend of the DST located approximately along the Syrian-Lebanese border Fig. 2b ; . The fault can be easily traced through the Mesozoic carbonate bedrocks mostly Upper Cretaceous limestones ; of the Anti-Lebanon Mountains to the eastern edge of the Bekaa Valley Gomez et al., 2003 ; . Results from paleoseismic investigations suggest an active fault with slip rates of around 1.4 mm year Fig. 3c; Gomez et al., 2001 ; . The long-term Late-Cenozoic uplift of the Lebanese coast 0.14 mm yr; Gomez et al., 2006 ; yields values of the exhumation between 2 and 2.5 km. Local uplift along smaller structures has been even greater Gomez et al., 2006. Recommendations 1. 2. CSC, public health departments, community health centers, and communitybased organizations should ensure that all HIV and HCV programs and services reflect these elements of good practice in all institutions. CSC should make every effort to improve the level of institutional confidentiality, particularly in the case of HIV and HCV infection. This must include improving the security of medical information, and the revision of and atarax. Net sales generated by sanofi-aventis in the first quarter of 2006 were 7, 035 million, up 9.6% on a reported basis. Gross profit was 5, 457 million, 10.0% higher than in the first quarter of 2005. The gross margin ratio rose by 0.3 of a point to 77.6%, compared to 77.3% for the first quarter of 2005, thanks to an increase of 18.9% in other revenues. Despite the impact of generics of Allegra, Amaryl, Agava and DDAVP, the ratio of cost of sales to net sales was unchanged. Research and development expenses were 13.3% up on the first quarter of 2005 at 1, 046 million. This rise reflects increasing Phase III clinical trials activity in pharmaceuticals and greater investment in R&D in the vaccines business. Research and development expenses represented 14.9% of net sales, compared to 14.4% in the first quarter of 2005. Selling and general expenses rose by 6.8% relative to the first quarter of 2005 to 2, 050 million, representing 29.1 % of net sales. Selling expenses rose sharply, but general expenses were lower yearon-year. Operating income current was 12.9% higher at 2, 419 million and represented 34.4% of net sales, a 1-point improvement on the 2005 first-quarter figure. Other operating income and expenses came to 533 million, against 17 million in the first quarter of 2005. The 2006 figure includes gains on disposals of 550 million, including 461 million on Exubera 384 million after tax ; and 45 million on the sale of the remaining 30% of the Animal Nutrition business. Operating income was up 37.4% at 2, 951 million. Net financial expense came to 30 million, against 106 million in the first quarter of 2005. This substantial fall was mainly attributable to a reduction in total debt due to the cash flow generated by the Group. Interest expense on debt totaled 73 million, compared to 129 million in the first quarter of 2005. Net financial expense also benefited from net gains on financial instruments 37 million, vs. 10 million in the first quarter of 2005 ; . Income tax expense came to 832 million, against 650 million for the first quarter of 2005, giving an effective tax rate of 28.5%, against 31.8% for the first quarter of 2005. Excluding the gain on the disposal of Exubera, the effective tax rate for the quarter was 30.7% 2005: 31.8.
In my opinion Dr B breached Rights 4 1 ; and 4 2 ; of the Code in the course of providing medical services to Mrs A. These provisions are supported by the statements in the New Zealand Medical Association `Code of Ethics' 1989 ; that individual doctors "ensure that every patient receives a complete and thorough examination into their complaint or condition" and that "accurate records of fact are kept". 13 October Mrs A returned to see Dr B on October. The presenting symptom was oesophageal reflux discomfort. Mrs A also informed Dr B that she had noticed a lump in the left lower area of her abdomen. Dr B recorded in the clinical records for this visit that Mrs A was complaining of a recurrence of oesophageal reflux. He prescribed further medication for this condition and told her that if her symptoms did not settle he would refer her for a gastroscopy. He also noted that she showed him the lump in her abdomen. Both Mrs A and Dr B agree that she stood while he examined the lump. My expert advised that this examination was not ideal, and that the correct method is for the patient to be supine on an examination table. My general practitioner expert advised that opinion is divided about the appropriate examination of an abdominal sebaceous cyst. A supine examination is appropriate to exclude abnormal abdominal and pelvic anatomy, while an examination when standing is useful to exclude problems such as hernia. My expert noted that although Dr B stated that he had found a surface epidermal cyst, Mrs A disagreed: "I have had problems with sebaceous cysts for years and they were always on or near the surface." My expert commented that dissonance between patient-described symptoms and the doctor's notes is not unusual. I accept my expert's advice that despite Dr B's belief that he was examining a sebaceous cyst on 13 October, it would have been appropriate for him to perform an abdominal pelvic examination at that time. Follow-up of referral for further tests On 13 October 2000 Mrs A mentioned to Dr B, as one of the conditions she was concerned about at that time, that she had discovered a lump in the region of her abdominal scar. Dr B suggested to her that an ultrasound examination would be helpful. When Dr B began to fill out a radiology referral form for an ultrasound examination, Mrs A informed him that she would organise this herself at the clinic next to where she worked. Dr B informed me that it was not his usual practice to have a patient arrange her own ultrasound. Dr B recorded in his notes: "O e surface epidermal cyst. U s to view below cyst TBA self in own practice ; ." My general practitioner expert advised that he had initially interpreted Dr B's note of "below" to mean that it was his intention to ultrasound Mrs A's pelvis in the area below the. Ebenhahn C, Verda AM, PierreJustin N, Dehaud S, Van den Berghe C, Mariani M Nietgen AM, Schrage NF, Reim M, Frentz W, Becker J, Salla S Optimization of a human corneal epithelial cell line: a possible tool to assess irritation potential of cosmetics and chemical compounds 30 min ; "in vitro" cornea model a new opportunity: organ culture and a test system replacing in vivo experiments 15 min ; Which ophthalmic preservatives are safe? 20 min ; New Tools in drug discovery and toxicity testing 15 min ; Applicability of an organotypic retinal culture as a drug testing system 15 min.

Mller P., Geyer S., Rosenthal E., Guttman Y., Dulski P. & Flexer A. einger. ; : Sources of salination of groundwater along the Jordan - Dead Sea - Red Sea transform: around Lake Kinneret, the Arava Valley Israel ; , and in adjoining territories, Chem. Geol. Mook W.G. 2001 ; : UNESCO IAEA Series on Environmental Isotopes in the Hydrological Circle Principles and Applications. Vol. I, IAEA, online-Publikation: iaeh programmes ripc ih volumes Nathan Y. 1969 ; : Studies on Palygorskite. unverff. MSc.-Arbeit, Hebrew University of Jerusalem, 153 p. in Hebrisch ; . Nathan Y., Shiloni Y., Roded R., Gal I. & Deutsch Y. 1979 ; : The geochemistry of the northern and central Negev phosphorites southern Israel ; . Geol. Surv. Isr. Bull. 43: 41. Nativ R., Adar E., Dahan O. & Nissim I. 1997 ; : Water salinization in arid regions observations from the Negev dessert, Israel. J. Hydrol. 196: 271-296. Nelson B.J., Wood S.A. & Osiensky J.I. 2003 ; : Partitioning of REE between solution and particulate matter in natural waters: a filtration study. J. Solid State Chem. 171: 51-56. Neumann J. & G. Stanhill 1979 ; : The general meteorological background. In: Serruya C. [ed.]: Lake Kinneret. Monographiae Biologicae, 32, Dr. W Junk bv Publishers The Hague-BostonLondon. Nishri A. & Koren N. 1993 ; : Sediment transport in Lake Kinneret. Verh. Internat. Verein. Limnol. 25: 290-292. Nishri A., Stiller M., Rimmer A., Geifman Y. & Krom M. 1999 ; : Lake Kinneret The Sea of Galilee ; : the effects of diversion of external salinity sources and the probable chemical composition of the internal salinity sources. Chem. Geol. 158: 37-52. Nishri A., Imberger J., Eckert W., Ostrovsky I. & Geifman Y. 2000 ; : The physical regime and the respective biogeochemical processes in the lower water mass of Lake Kinneret. Limnol. Oceanogr. 45 4 ; : 972-981. Nsslein B., Eckert W. & Conrad R. 2003 ; : Stable isotope biogeochemistry of methane formation in profundal sediments of Lake Kinneret Israel ; . Limnol. Oceanogr. 48 4 ; : 1439-1446. Osmond J. K. & Cowart J. B. 1992 ; : Ground water. S. 290334. In: Ivanovich M. & Harmon R.S. [Edn]: Uranium-Series Disequilibrium: Applications to Marine and Environmental Problems Clarendon Press, 2. Auflage. Paces T., Mller P., Fuganti A., Morteani G. & Pecek J. 2001 ; : Sparkling mineral water at western rim of the Doupovske hory Mountains Czech Republic ; : genesis by water-rock interaction and deep-seated CO2. Bull. Czech Geol. Surv. 76: 189-202. Petters S.W. 1991 ; : Regional Geology of Africa. Lecture Notes in Earth Sciences, 40, p. 608-621. aus: : geo.tu-freiberg oberseminar os02 03 claudia twarz ; Picard L. 1931 ; : Geological researches in the Judean Dessert. Goldberg Press Jerusalem. 108 S. Picard L. 1959 ; : Geology and oil exploration in Israel. Bull. Res. Coun. Israel. 8G 1 ; : 1-30. Pollinger U. 1986 ; : Phytoplankton periodicity in a subtropical lake Lake Kinneret, Israel ; . Hydrobiologia. 138: 127-138.

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