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TABLE 3. EXAMPLES OF DRUGS THAT CAUSE ALTERED TASTE OR DYSGUESIA Cardiac Drugs Antiasthma Acetazolamide Diamox ; Captopril Capotdn ; Gemfibrozil Lopid ; Terbutaline Brethine, Bricanyl ; Dactinomycin actinomycin-D ; Quinidine Quinaglute Dura, Quinidex Extentabs, Quinora ; Beclomethasone Beconase, Vancenase ; Cisplatin Platinol-AQ ; Interferon alfa 2a Roferon-A ; Cefuroxime Ceftin, Zinacef ; Clotrimazole Mycelex ; Metronidazole Flagyl ; Levodopa Dopar, Larodopa ; Docusate Sodium Colace ; Didanosine Videx ; Pyrimethamine Daraprim ; Rifabutin Mycobutin ; Phenytoin Dilantin ; Sumatriptan Succinate Imitrex ; Selenium Se ; Fluorouracil 5-FU ; Adrucil ; Antiinfectives Amprenavir Agenerase ; Clarithromycin Biaxin ; Ethionamide Trecator-Sc ; CNS Drugs Miscellaneous Clomipramine Anafranil ; Disulfiram Antabuse ; Antineoplastics Carboplatin Paraplatin.

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Effective prophylaxis against PCP can be achieved by administering low, intermittent doses of TMP-SMX. One double-strength tablet of TMP-SMX twice a day for three consecutive days a week has a high degree of efficacy in preventing PCP.31 PCP has a mortality rate of up to percent in cancer patients, reinforcing the need for prophylaxis.28 Cancer patients who require prophylaxis include those with defects in cell-mediated immunity and those undergoing Allo-BMT. Consideration of prophylaxis for cancer patients receiving high-dose corticosteroids should also be given.28 Although TMP-SMX is the drug of choice for PCP prophylaxis, the use of aerosolized pentamidine is an effective alternative in cancer patients who are intolerant to TMP-SMX.32 Other alternatives include intravenous pentamidine every two to four weeks or oral daily dapsone. Because efficacy of these alternative agents has been shown in HIV patients, it is assumed they are effective in other immunocompromised patients as well. Occasionally, other protozoans can cause serious pulmonary disease in cancer patients. Strongyloides stercoralis should be anticipated in patients who have been exposed to Strongyloides infection any time in their lifetime and then develop illness or receive treatment that affects helper T-cell function.33 The diagnosis should be considered in any immunosuppressed patient who comes from an endemic area and develops vague abdominal symptoms of pain, diffuse tenderness, or distention and then develops pneumonia. Although blood cultures may be positive for one or more bacteria from the gut flora, the diagnosis is made by demonstrating the filariform larvae in sputum or other respiratory tract specimens, especially bronchoalveolar lavage fluid. The larvae may also be found in feces or in cerebrospinal fluid if meningitis occurs. Standard therapy for strongyloidiasis is thiabendazole. The duration of.

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Hypertension. 2003; 42: 878. ; . A randomeffects model was used to account for heterogeneity among trials. A net weight reduction of 5.1 kg by means of e n restriction, increased p h y activity, or both reduced systolic blood pressure by -4.44 mm Hg and diastolic blood pressure by -3.57 mm Hg 95% CI, -4.88 to -2.25 ; . Blood pressure reductions were -1.05 mm Hg systolic and -0.92 mm Hg diastolic w h e expressed p e r kilogram of weight E W S loss. As expected, significantly larger blood pressure reductions were observed in populations with an average weight loss 5 kg than in populations with less weight loss, both for systolic and diastolic blood pressure. The effect on diastolic blood pressure was significantly larger in populations taking antihypertensive drugs than in untreated populations. This metaanalysis clearly shows that weight loss is important for the prevention and treatment of hypertension, for instance, hypertension.

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Studies conducted of alcohol tobacco is duricef infected monkeys capoten label and carbidopa. 1259. Phase I study of gemcitabine and radiotherapy plus cisplatin after transurethral resection as conservative treatment for infiltrating bladder cancer - Caffo O., Fellin G., Graffer U. et al. [Dr. O. Caffo, Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy] - INT. J. RADIAT. ONCOL. BIOL. PHYS. 2003 57 5 ; - summ in ENGL Purpose: Although the use of radical transurethral resection followed by concurrent radiochemotherapy leads to a similar survival rate to that achieved after cystectomy, the number of long-term survivors is low in both cases. An improvement may be obtained by adding a new drug, such as gemcitabine, which is active in bladder cancer and acts as a radiosensitizer. However, because gemcitabine may be very toxic when associated with radiotherapy, we designed this dose-finding study in an attempt to find the dose that can be safely added to radiotherapy and concurrent cisplatin in patients treated with transurethral resection for infiltrating bladder cancer. Patients and Methods: After undergoing macroscopically complete transurethral resections for transitional carcinoma of the bladder, patients staged pT2 or higher and without distant metastases concurrently received 54 Gy of fractionated radiotherapy over 6 weeks with cisplatin 100 mg m2 q.3 w ; , starting on Day 1 of radiotherapy. Concomitant gemcitabine was administered on Days 1, 8, and 15 q.3 w for 2 cycles at a dose of 200 mg m2 , escalated to 500 mg m 2 , with a 100 mg m2 increase at each dose level. The maximum tolerated dose was defined as the dose of gemcitabine associated with dose-limiting toxic effects febrile neutropenia, Grade 4 thrombocytopenia, Grade 3 or 4 enteric toxicity, or Grade 4 nonhematologic toxicity ; in 33% of the patients treated at that dose level. Six to 8 weeks after completing the therapy, the patients underwent cystoscopic reevaluation with multiple biopsies of the initial tumor site. Results: Of our consecutive series of 16 patients, 5 received a gemcitabine dose of 200 mg m2 week, 3 a dose of 300 mg m2 week, 3 a dose of 400 mg m2 week, and 5 a dose of 500 mg m2 week for 6 weeks. No dose-limiting toxicity was observed at doses of up to 400 mg m2 week. At the dose 500 mg m 2 week, 1 patient experienced an intestinal perforation that recovered after surgery, and another suddenly died after developing Grade 3 untreated diarrhea in the last treatment week. All of the 15 evaluable patients were microscopically disease free at the cystoscopic reevaluation; furthermore, the posttreatment computed tomography scans did not reveal any distant metastases. Conclusions: After transurethral resection for the conservative treatment of infiltrating bladder cancer, gemcitabine doses of up to 400 mg m2 week seem to be safe in combination with cisplatin and radiotherapy in organsparing management. On the basis of the promising results of this Phase I study, we are currently conducting a Phase II trial to verify the possible improvement in local control resulting from the addition of gemcitabine. 2003 Elsevier Inc. 1260. 2-Chloro-deoxyadenosine Induces Durable Complete Remission in Castleman's Disease but may Accelerate its Transformation to Non-Hodgkin's Lymphoma - Colleoni G.W.B., Duarte L.C.C., Kerbauy F.R. et al. [G.W.B. Colleoni, Andar Hematologia, Rua Botucatu, 740-3, CEP 04023-900 S~ o Paulo, a Brazil] - ACTA ONCOL. 2003 42 7 ; - summ in ENGL There is currently no consensus on the best treatment for unresectable hyaline-vascular variant or for multicentric Castleman's disease MCD ; , because none of the reported regimens have consistently produced complete response or durable remission in the majority of patients. In the present study, we report on the use of 2-CdA 2-chloro-deoxyadenosine ; in three patients, two of them with MCD and one with unresectable hyaline-vascular type disease. Relapse-free survival of the responding patients was 24 and 20 months. Later, both patients evolved to non-Hodgkin's lymphoma NHL ; diffuse large B-cell lymphoma and peripheral T-cell NHL, respectively ; . 2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use. Therefore, it is reasonable to conclude that: 1 ; 2-CdA can induce durable complete remission in MCD patients but unfortunately it cannot cure the disease; 2 ; the possibility that 2-CdA may accelerate the transformation of MCD to NHL cannot be ruled out. Section 38 vol 39.2.

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Chopra and Chopra6 state that it can persist long after the narcotic effect has disappeared. They also stated that in most addicts a permanent congestion of the transverse ciliary vessels develops. One addict interviewed showed this congestion and his addiction had been of many years standing. A marked proneness to tachycardia on exertion or a sustained sinus tachycardia was shown by all subjects. Even allowing for excitement or tension or muscular activity there appeared to be a definite autonomic imbalance. Dryness of the mouth was universal and marked, almost like an atropine effect, but dilatation of the pupils, if it existed at all, was only slight. Paraesthesiae in the extremities and peri-oral area was a marked feature in all cases, and in the case who took forty-eight grains it was accompanied by a subjective feeling of weakness of the extremities. The more florid symptoms were a disorder of visual perception, the appearance of formed visual images, usually intricate, when the eyes were closed, bizarre disorder of body perception and a marked feeling of dissociation not only of self, so that the subject of the experiment often said he felt as though he were the observer of the experiment, but also of the various functions of self, so that action, volition, thought and effect became chaotically disorganized. The abnormalities of movement, which in a mild form consisted of periodic contraction of isolated muscle groups, or occasional writhing movements and in a severe form were a continuous medley of movements, are noteworthy because they are so difficult to classify. Beringer observed a great variety of motor anomalies including hyperkinetic and hypokinetic states. Walton * ' mentions a medical man, Burr, who took cannabis and "suffered a general convulsion which lasted three minutes; he felt well; his speech was not affected. The convulsion resembled an attack of hysteria . the convulsions appeared willful in that he willed to convulse; he knew that he was throwing his arms about, that he was writhing like a snake, acting like a clown, making silly grimaces. But he could not will to do otherwise. He could restrain a convulsion for a few minutes, but soon the will to convulse overcame the will to inhibit." This description is very like the state seen in one subject on two separate occasions, though the use of the term "convulsion" is unfortunate. One is also.

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Research note j int med res 2004; 32 6 ; : 590-607 comparative clinical study of cefcapene pivoxil and cefteram pivoxil in chronic respiratory tract infections by a double-blind method a saito 1 , y hiraga 2 , a watanabe 3 , a saito 4 , k shimada 5 , h kobayashi 6 , s odagiri 7 , f miki 8 , r soejima 9 , k oizumi 10 , k hara 11 , m nakashima 12 , the japanese cefcapene study group 13 1 first department of internal medicine, faculty of medicine, university of the ryukyus, okinawa, japan; 2 department of respiratory diseases, sapporo hospital of hokkaido railway company, sapporo, japan; 3 department of respiratory medicine, division of cancer control, institute of development, ageing and cancer, tohoku university and related hospitals, sendai, japan; 4 second department of internal medicine, the jikei university school of medicine and related hospitals, tokyo, japan; 5 department of infectious diseases and applied immunology, institute of medical science, the university of tokyo and related hospitals, tokyo, japan; 6 first department of internal medicine, kyorin university school of medicine, mitaka, japan; 7 department of respiratory diseases, kanagawa prefectural cardiovascular and respiratory diseases center, yokohama, japan; 8 department of internal medicine, tane general hospital, osaka, japan; 9 division of respiratory diseases, department of medicine, kawasaki medical school, kurashiki, japan; 10 first department of internal medicine, kurume university medical school, kurume, japan; 11 the second department of internal medicine, nagasaki university school of medicine, nagasaki, japan; 12 department of pharmacology, hamamatsu university school of medicine, hamamatsu, japan; 13 see appendix in a double-blind study, the efficacy and safety of the novel cephem antibiotic cefcapene pivoxil cfpn-pi; 450 mg day ; was compared with cefteram pivoxil cftm-pi; 600 mg day ; in 171 patients with chronic respiratory tract infections and carvedilol.

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451 A model for the study of dead and down pigs associated with transport: effects of maternal pheromone on pigs in transit. C. Lewis * 1, 2, N. Krebs1, 2, L. Hulbert1, 2, and J. McGlone1, 2, 1Pork Industry Institute, Lubbock, TX, 2Texas Tech University, Lubbock. The objectives of this study were: 1 ; to establish a model for the study of dead and down DD ; pigs associated with transport and 2 ; to evaluate the effects of the maternal pheromone MP ; Suilence Ceva, France ; on DD rates. Humanpig interactions were observed during handling audits at the farm during truck loading and at the packing plant during unloading and movement to stun and kill. 30 trucks were observed which contained a total of 5, 169 pigs ~164 pigs per truck ; . The pigs traveled ~45 min during transport, in the summertime. The truck was the experimental unit. At the farm, observers were blind to treatment and randomly selected trucks to receive MP or a control CO ; containing the solvent used to deliver MP. MP or CO was evenly sprayed on each truck 500 ml ; . They recorded the number of pigs that slipped fell S ; , vocalized V ; , reared R ; and the number of pigs touched with an electric prod E ; at the farm only; prods were not used at truck unloading ; by using live continuous observation methods. The numbers of pigs that were DD at truck unloading, in rest pens or pre-stun were recorded. The completely random design was analyzed as a simple ANOVA with two treatments. The rate of pig death was low 0 on the trucks, and 0.00080.0007 & 0.00070.0007 respectively in the pre stun area ; . At truck loading the rate of pig S, V, R, and E for CO and MP were not different S: 0.0140.007 & 0.0320.007, V: 0.870.08 & 0.720.08, R: 0.0480.08 & 0.030.08, E: 1.150.15 & 1.040.15, respectively ; . V were higher P 0.03 ; among CO than MP at the pre-stun area 0.140.015 & 0.090.015 for CO and MP respectively ; . A power analysis determined that the number of trucks needed to detect a 50% difference for S, V, R, E at the farm ; and NANI at the plant ; were 144, 16, 66, trucks, respectively. While mean improvements in the rate of down pigs and associated pig handling measures are suggested, studies of this type require over 200 trucks to detect meaningful differences. Key Words: Swine Transportation, Swine Handling, Swine Stress. Gedeon Richter is a mid sized pharma company with a regionally vertically integrated structure. This is based on a good market position with geographic and therapeutic niches, continuous enhancement of the supply of specialities partly via licencing agreements, branded generic products in addition to ongoing research in the central nervous disease area. During the early to mid 1990's in a time of privatisation and establishment of new management, the Company's therapeutic portfolio became more focused. With this background it is understandable that most of the top 10 products in 2006 originate from the three largest therapeutic categories. Gynaecological, cardiovascular and central nervous system products together generated almost 70 percent of total Company sales in 2006 and cilostazol.
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Received hormone injections at 1-h intervals for 5 h, beginning 10 min after the injection of toxin. The results of these experiments are shown in Tables 2 and 3. Epinephrine provided only minor protection against plague intoxication when administered at 1-h intervals. The adrenergic hormone provided little or no protection to animals receiving a single injection. In addition, epinephrine failed to produce an alteration in the mean time of death. In contrast, glucagon Table 3 ; provided up to 71% protection from lethality and an increase of up to 60% 8.1 to 13 h ; the mean time of death. Thus, it can be concluded that and clarinex.
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A combined approach of oral topical mechanical therapies may increase efficacy rates. In lateral onychomycosis, the concentration of the oral antifungal agent is lower in the lateral portion of the nail plate, and combining it with ciclopirox nail lacquer may help improve efficacy by providing drug to this area of the nail.15 Patients may benefit from the use of ciclopirox nail lacquer applied twice weekly7, 11 as a means of preventing recurrence. However, the benefit of prophylactic treatment needs to be confirmed in controlled trials and clindamycin.
Hospital Purpose: To evaluate an innovative, functional prototype of pharmacist best-practice in an interdisciplinary primary care team. The goals were to conduct a process evaluation to characterize activities and functions that were needed to meet the needs of the team and explore processes and structures used by the pharmacist to contribute to collaborative medication management CMM ; . Methods: This study used mixed quantitative and qualitative ; methods: a ; a retrospective chart review of 105 patients to study the type of drug-related problems and their relationship to pharmacist's role and pharmacist-physician collaboration; and b ; a grounded theory method to data collection and analysis of case scenarios of pharmacist's involvement in patient cases to identify key categories, their properties, and relationships to the pharmacist's role in CMM. Results: The findings revealed that in addition to the philosophy of pharmaceutical care, there are six more principles that need to guide pharmacist practice in CMM. To contribute to CMM pharmacists will need to become competent to perform multiple functions that form a foundation for a repertoire of core expertise. A key finding was the characterization of a reflective approach that defines the nature of involvement and level of pharmacist responsibility in different patient situations which is an essential reflective competency that will need to be acquired by pharmacists if they are to integrate effectively into primary care teams. Conclusions: There is large variability in the functions and the nature of involvement potentially required of a pharmacist in primary care, thus pharmacy students will need to become highly reflective practitioners competent to perform a wide repertoire of specific expanded patient care functions. Parts of the results were previously presented: CSHP Professional Practice Conference, January 2004. Also parts of the study have been submitted for presentations as poster or oral presentation at the following conferences but results of the reviews are still pending: Qualitative Health Research Conference, April 2004; CPhA Annual Meeting, May 2004; Canadian College of Clinical Pharmacy Conference, June 2004. PPR No. 2: Involvement of a community pharmacist research network in evaluating outcomes of bisphosphonate therapy.

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These specific challenges were acknowledged at the Eighth International Conference of Drug Regulatory Authorities ICDRA ; , in Bahrain in1996. WHO Member States were encouraged to establish groups of experts for herbal medicines in their own countries and regions and to update national legislation in order to allow registration of herbal medicinal products. This was reconfirmed at the Ninth ICDRA in Berlin in 1999. In 1996, the European Parliament requested facilitated systems for marketing of herbal medicinal products; and in 1997 a specific Herbal Medicinal Products Working Party was created at the European Medicines Evaluation Agency EMEA ; . A permanent working group is now composed of delegates from all member countries of the European Union, experts and observers from future new member countries, the European Commission, European Parliament and European Pharmacopoeia. The main focus of the group is to facilitate mutual recognition of marketing authorizations within the European Union by preparing guidance for documentation and assessment of quality, safety and efficacy of herbal medicines. In addition to these tasks, the group may give advice on pharmacovigilance action and on future legislation. All documents prepared by the group are available from : emea .int. The work of the group is complemented by the European Pharmacopoeia that has established two working parties to prepare general and specific monographs on herbal drugs. These monographs are fully integrated into the official European Pharmacopoeia.
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Special precautions: call your physician or pharmacist if you are allergic to candesartan, benazepril lotensin ; , captopril capoten ; , enalapril vasotec ; , fosinopril monopril ; , hydrochlorothiazide hydrodiuril ; , irbesartan avapro ; , lisinopril prinivil, zestril ; , losartan cozaar ; , moexipril univasc ; , quinapril accupril ; , ramipril altace ; , sulfas, telmisartan micardis ; , trandolapril mavik ; , valsartan diovan ; , or any other drugs.

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Psycho-social distress. Clients who show apathy and pessimism, a decline in social functioning prefer to stay at home, don't want to receive visits ; , lack family support or financial resources, display dissatisfaction with health care providers or have poor motivation are at risk of poor compliance. The goal is to enhance motivation. Ensure that the client understands the need and usefulness of a given treatment, as well as the importance of his or her collaboration. Recognize that poor adherence may be due to causes that the client is reticent to reveal: lack of financial resources or family support. A sensitive tactful investigation will help to establish a good client-caregiver relationship, hopefully facilitating the client's adherence.
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Abeta . 570 agents affecting enzymes mediating . 570 Abeta immunotherapy . 569 in amyloid . 569 Acute ischemic stroke . 110 clinical studies in . 110 preclinical studies on . 110 Adenosine . 326 in cerebral ischemia . 327 in hypoxia . 327 in trauma . 327 Age-related cognitive decline . 534 differences in . 534 Ajulemic acid . 521 adhesion molecules in . 227 Alzheimer's disease . 223, 249, 283, advanced glycation endproducts AGEs ; in . 251 alternative inhibitors for . 562 amphotercin HMGB-1 in . 253 amyloid angiopathy in . 223 amyloid associated factors in . 241 amyloid associated proteins in . 235 amyloid associated proteins in transgenic animal studies of . 240 amyloid driven cascade of . 244 amyloid peptide A ; in . 224, 251 1-antichymotrypsin in . 238 apolipoprotein E in . 239 as target for therapeutics in . 553 associated neurotoxic mechanisms of . 383 A production aggregation in . 283 brain changes in . 226 central role for A in . 283 changes of mitogenic ECM signaling in . 301 cholesterol in . 556 clinical trials of . 308, 561 clusterin in . 239 complement in . 237 COX-1 in . 307 cystatin C in . 238 disturbances of kinase phosphatase activities in . 302 disturbances of RNA synthesis in . 302 DNA damage in . 301 drug targets of . 559 early neuronal changes in . 227 epidemiological studies of . 308 epidemiological studies of . 560 experimental models of . 435 gene findings in . 227 glycosaminoglycans in . 239 immunohistochemical data of . 227 impaired DNA repair in . 301 inflammation in . 224, 227 inflammation in transgenic models of . 229 intracellular A in . 283 intraneuronal A in . 283 2-macroglobulin in . 238 microglia in . 226 microglial activation in vivo in . 241 models of . 443 neuroinflammation in . 307 neuronal COX-2 in pathogenesis of . 311 neuroprotective compounds mechanisms in . 443 non-excitotoxic neurotoxins in . 443 non-steroidal anti-inflammatory drugs in . 307 pathological cascade of . 227 pathology of . 307 post-ER protein quality control in . 285 preventing RAGE activation as therapy for . 261 protease inhibitors in . 238 protein quality control in . 283, 285 RAGE-mediated inflammatory mechanisms in . 254 receptor for advanced glycation endproducts RAGE ; in . 249 redirection to ER in 285 redirection to lysosomes in . 285 S100 calgranulins in . 252 serum amyloid P component in . 238 statins in . 559 subcellular localization of A in 284 therapeutic approach to . 245 therapeutic implications of . 223, 229 ubiquitin proteasome system in . 286 AMPA receptors . 153 function of . 153 genes of . 153 in vitro properties of . 155 physiological function of . 153 structure of . 153 AMPA receptor antagonists . 153 effects of . 156 excitotoxicty by . 154 for treatment of stroke . 153 in clinical situation . 157 in disease-related animal models . 156 in vivo . 156 Amyloid . 569 activation of phagocytosis of . 569 Amyloid fibril disrupters . 593 Antioxidants . 571 Aplysia . 490 molecular synaptic mechanisms of memory storage in . 490 Apolipoprotein E . 553, 571 as target for Alzheimer's disease therapeutics . 553 in amyloid deposition . 571 Apolipoprotein E knock-in mouse . 135 permanent MCAO model in . 135 APP processing . 555 role of cholesterol in . 556 Arundic acid . 129 animal toxicology of . 130.
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Appendix Table 4. Measures of legal induced abortion, by country, and completeness of statistics. Prescription of medication without formal follow-up n 41.

Around TRIPS in a way that does not undermine our ability to get these medicines to the people who need them and continue to give us the ability to bring new therapies to people, because that is the only way we will ever solve any of these problems. So my emphasis on infrastructure and financing is real. If we had used the amount of energy that we have expended beating the brains out of sometimes politically tonedeaf pharmaceutical companies, if we had spent that level of energy concentrating on African governments to invest in healthcare, on the US and other developed countries to make more substantial contributions to the global fund, to reduce debt, I wonder where we would be today. You certainly have made great progress in getting the attention of multinational pharmaceutical companies. Declare victory, because in that way you did a very good service for people who are poor, because we are fully engaged in trying to figure out how to solve some of these problems. I think you should join us in figuring out ways to get medicines to people. Many different strategies work. We also have to work on our own Government and governments in developed countries to get their attention around this problem. If we could come together to do that, I think we would be a hell of a lot better off. Francisco Cannabrava I would like to refer briefly to the last comment. The truth is there are pretty much two sides, but I don't mean to say that there should be an antagonistic or that discussions should freeze on two sides. As a matter of fact, the exercise we are engaged in here exactly demonstrates that we are looking to sustainable and effective solutions, both within the domain of IP rules and outside. The focus today happens to be on the effect that the IP system may have on public health and what we believe is that it should definitely operate in favour of those objectives. I agree with Mr Mallett on the fact that TRIPS is both a political and legal document. I think that this is very important to bear in mind because we should not take the TRIPS Agreement from a narrow perspective of what is the least of flexibilities that we can achieve from that. The TRIPS Agreement contains very important provisions that take into account the need of developing countries to promote social and economic welfare. Under this context we should try to look for ways of implementing TRIPS in a way that is simply going to both preserve patent rights, and try to avoid abuses of those rights. I don't think that anyone who is interested in preserving patent rights should defend a point of view that they should be absolute or sacrosanct. It is just a matter of preserving the legitimate goals of countries of pursuing public health policies. My final point is to stress the important element of countries with insufficient or no manufacturing capacity which I think is one important element to be taken into consideration in your recommendations. I would like to praise the Commission for organising this conference, because generic name.

Albeit a relatively new practice in the life sciences sector, the importance of IAM in creating and sustaining high-growth, highcapital value companies has been recognised in a number of countries, a good example being the Singapore IP Academy which was for med in 2003. Over in Scotland, meanwhile, IAM considerations have not only led to the formation of a primary partnership between two life sciences companies and an `innovation fund', but have helped to map the onward partnering opportunities for the outputs of the primary alliance. Also established in 2003, ITI Scotland comprises three `Intermediary Technology Institutes', each centred on a key industrial sector, one of which is the life sciences. Each institute manages a substantial innovation fund of approximately 150 million US$282 million ; over ten years, financing the generation of technology-based innovations for which there is demonstrable market demand.The aim of this organisation is to stimulate and benefit the Scottish economy in the long term, by bridging the innovation gap that frequently exists between early-stage, publicly-funded research and privately-funded technological development. At the core of ITI operations is a robust IAM model. This seeks to ensure that the technologies developed have the broadest IPR protection, the maximum freedom to operate, and a clear onward route to market via partner organisations, which it calls `programme participants', effectively licensees. In selecting such companies, the ITI obviously requires that the partner be operationally capable of meeting the market opportunity, and that in so doing, it will be contributing to the growth of the Scottish biotech industry. However, it is also diligent. The table below lists the agents covered in this review. Brand-name examples are cited for familiarity. Some agents are available in OTC formulations, which are listed as well.

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